Allah's Messenger (ﷺ) said, "Shall I inform you of the biggest of the great sins?" They said, "Yes, O Allah's Apostle!" He said, "To join partners in worship with Allah, and to be undutiful to one's parents. "
Reference: Sahih al-Bukhari 6273 In-book : Book 79, Hadith 47 USC-MSA web (English) : Vol. 8, Book 74, Hadith 290 (deprecated)
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